Testing whether avoiding the hippocampus in addition to memantine

Primary Objective Determine whether the addition of HA-WBRT increases time to neurocognitive failure at months 2, 4, 6 and 12 as measured by neurocognitive decline on a battery of tests: the Hopkins Verbal Learning Test-Revised (HVLT-R) for Total Recall, Delayed Recall, and Delayed Recognition, Controlled Oral Word Association (COWA), and the Trail Making Test (TMT) Parts A and B. 1.2 Secondary Objectives 1.2.1 Determine whether the addition of HA-WBRT preserves neurocognitive function at months 2, 4, 6 and 12 as separately measured by each test, the HVLT-R for Total Recall, Delayed Recall, and Delayed Recognition; COWA; and TMT Parts A and B. 1.2.2 Evaluate the potential benefit of HA-WBRT in symptom burden, as measured by the M. D. Anderson Symptom Inventory-Brain Tumor Module (MDASI-BT) 1.2.3 Assessment of quality adjusted survival and health outcomesusing the EQ-5D-5L. 1.2.4 Compare cumulative incidence of progression and overall survival after WBRT versus HA-WBRT. 1.2.5 Compare adverse events between the treatment arms according to the CTCAE v4.0 criteria.

November 16, 2016